Psoriasis

With a crowded indication that includes 14 systemic agents, is there really room for tyrosine kinase 2 (Tyk2) inhibitors to treat psoriasis? This physician thinks so.

The development of new biologics targeting a variety of dermatoses is on the upswing with some treatments coming to the clinic as early as this year, according to April Armstrong, M.D. who discussed the topic at the American Academy of Dermatology Spring Meeting in Washington, D.C.

Psoriasis treatment has expanded dramatically over the past decade, and the growth shows no signs of stopping. Andrew Blauvelt, M.D. discussed new drugs in the pipeline during American Academy of Dermatology Annual Meeting in Washington, D.C.

While this new class of medications still has a role in treating psoriasis, this physician says the standard for both their efficacy and safety is very high because of the existing, already very effective systemic therapies available today.

New guidelines from the American Academy of Dermatology and the National Psoriasis Foundation strongly support the use of a wide range of biologics to treat cases of psoriasis that are insufficiently resolved despite treatment with topical therapy, phototherapy or both. 

A decade ago, the list of psoriasis comorbidities didn't go much beyond psoriatic arthritis. Now, new guidelines warn dermatologists that many medical conditions are linked to psoriasis, from cardiovascular disease and metabolic syndrome to cancer, renal and hepatic disease and even the eye condition uveitis.

Researchers recently performed a control trial to test the efficacy of BMS-986165 a potent TYK2 inhibitor. Here's what they found.

Researchers at The Cleveland Clinic Lerner College of Medicine recently explored the development of a psoriasiform rash in patients with inflammatory bowel disease or rheumatoid arthritis who were treated with TNF-ɑ inhibitors. Learn what they discovered in this article.

A recent survey asks dermatologists who treat patients with moderate to severe psoriasis about the greatest unmet needs of this patient group. Here's what physicians had to say.

A recent study suggests that patients suffering from psoriasis and psoriatic arthritis may have an increased risk of developing autoimmune thyroid disease. 

Having psoriasis gives a patient a 1.75-fold increased odds of developing ulcerative colitis and a 1.70-fold increased odds of developing Crohn's disease.

Doctors should be vigilant about recognizing the signs and symptoms of patients who may develop ILD in order to prevent catastrophic complications, such as respiratory failure.

Increased mortality described in the first study to review all-cause mortality and cause-specific mortality in patients with psoriasis.

Sandoz, a division of Novartis, announced that the U.S. Food and Drug Administration approved its biosimilar, adalimumabadaz (Hyrimoz, Novartis AG). 

The National Psoriasis Foundation and the National Eczema Association have awarded Procter & Gamble’s Tide Free and Gentle Liquid Laundry Detergent and Tide PODS Free and Gentle Laundry Detergent a “Seal of Recognition” and “Seal of Acceptance” for people with eczema or sensitive skin.

The TNF alpha inhibitor certolizumab pegol (Cimzia, UCB) has achieved the highest response rates seen in phase three trials of self-injectable biologics for psoriasis.

Biologic tildrakizumab-asmn approved with suffix as differentiator from future biosimilar versions.

Wound healing is impaired in both psoriasis and multiple sclerosis. Understanding the pathophysiology of these two chronic conditions is vital to generating and improving treatment targets.

Patients with early-onset psoriasis are less likely than those with late-onset psoriasis to respond to systemic psoriasis treatments, a scientific review shows.

A review of more than 5,000 patients with moderate to severe plaque psoriasis who were treated with ixekizumab over three years, shows no unexpected safety signals.

Signs of aortic vascular inflammation in psoriasis patients may indicate early signs of coronary artery disease, report researchers writing in the Sept. 12 issue of JAMA Cardiology.

Psoriasis is associated with a host of comorbidities, such as obesity and the metabolic syndrome. In this study, researchers show that fatty liver disease is often the first sign of worsening health.

Researcher experiments with reformulating psoriasis topical as a lotion instead of cream, which performed well with patients.

Women in treatment for skin diseases, including psoriasis, experience higher levels of non-psychotic psychiatric disorders, including anxiety and depression, than men.

For women with psoriasis, psoriatic arthritis, and ankylosing spondylitis who take secukinumab during pregnancy or conception, recent research shows adverse pregnancy events don’t happen at a higher rate.

Developing psoriasis during childhood or adolescence can affect self-esteem. Dr. Amy Paller discussed the impact of psoriasis on adolescents, and treatment options, during the annual NPR Residents Meeting.

From obesity to heart disease, patients with psoriasis have a host of comorbidities and most rely on their dermatologist for comprehensive care.

For psoriasis patients, the most common comorbidity they may experience is psoriatic arthritis. Knowing how to identify and treat it can be critical.

Biologics certainly have shown to be an effective treatment in plaque psoriasis, but physicians should not discount more traditional therapies for treating psoriasis.

Understanding measures of psoriasis disease severity is critical for the patient. And, many payers, including the Centers for Medicare and Medicaid Service require an accurate PASI or PGA score on all psoriasis claims.