Overview of CSU Symptoms

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EP: 1.Overview of CSU Symptoms

EP: 2.Current and Emerging CSU Therapies

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Chronic spontaneous urticaria (CSU) is a recurrent and unpredictable inflammatory skin condition characterized by itchy wheals and angioedema, affecting approximately 63% of patients with moderate to severe itch. Dr Gil Yosipovitch, Professor of Dermatology and Stiefel Chair of Medical Dermatology at the University of Miami, emphasizes that CSU represents a clear clinical entity that dermatologists should actively diagnose and manage, moving beyond the traditional approach of leaving treatment solely to allergists.

The primary symptom burden in CSU patients centers on intense pruritus, which significantly impacts quality of life, particularly affecting sleep patterns and causing substantial anxiety and stress. The unpredictable nature of symptom flares creates psychological distress, as patients never know when symptoms will appear or worsen. Additionally, approximately 30% of CSU patients experience angioedema, which adds another layer of discomfort and concern to the clinical presentation.

Research comparing CSU patients to those with psoriasis reveals that CSU patients actually experience higher levels of anxiety and stress than psoriatic patients, highlighting the significant psychological impact of this condition. The combination of physical symptoms, sleep disruption, and psychological burden creates a complex clinical picture that requires comprehensive management approaches targeting both the physical manifestations and the emotional well-being of patients.