Evolving Acne Management

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EP: 1.Evolving Acne Management

EP: 2.The Role of Guidelines, Patients, and Payers in Acne Management

EP: 3.Selecting Patients for Oral Antibiotic Therapy

EP: 4.Exploring the Anti-Inflammatory Impact of Oral Antibiotics

Acne remains a prevalent chronic inflammatory skin condition that significantly impacts patients' quality of life. While oral antibiotics have long been a mainstay in acne management, their role is increasingly being reevaluated in the context of antimicrobial resistance and evolving therapeutic options. This program explores how modern treatment strategies aim to balance effective clinical outcomes with long-term safety by considering both scientific evidence and patient-specific factors.

Recent years have seen a meaningful shift away from the widespread use of broad-spectrum antibiotics toward more targeted therapies. This transition is largely influenced by growing awareness of the human microbiome, particularly the gut microbiota, which can be significantly disrupted by certain antibiotics. The preference for narrow-spectrum agents, such as those that minimize impact on gut flora, reflects a more nuanced and microbiome-conscious approach. In particular, the differentiation between broad- and narrow-spectrum tetracyclines has become increasingly important, given their dominant use in dermatologic care.

Additionally, nonantibiotic options are being integrated more frequently into acne treatment plans. Hormonal agents such as spironolactone and systemic treatments such as isotretinoin offer potent alternatives for specific patient populations. Rather than relying on a single approach, today’s acne management involves a comprehensive tool kit, tailored to the unique clinical and personal needs of each individual. The emphasis is on thoughtful prescribing that mitigates resistance risks, protects the microbiome, and maximizes therapeutic success.