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and joined the MJH Life Sciences team in February 2023. She attended Kent State University and earned a Bachelor of Science degree in journalism with minors in public relations and creative writing. She enjoys making and listening to music, reading, and spending time with her cats, Astrid and Marceline.

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Explore the top headlines of the week including insights on the latest clinical trials, therapeutic updates, and more.

Dermatology Times' Weekly Crossword: June 22, 2025

Marie Bosslett is the assistant editor of 

 and joined the MJH Life Sciences team in October 2024. She attended Loyola University Maryland in Baltimore and earned a Bachelor of Arts in Communication with minors in marketing and writing. When she’s not writing, Marie enjoys going to concerts, reading on the beach, and spending time with friends and family.

In case you missed it, this week we had news about the FDA approval of dupilumab for bullous pemphigoid, the upcoming INTEGUMENT-INFANT trial for roflumilast, nail trends that challenge clinical diagnosis, and more.

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This week, we feature top articles from our sister publications on regulatory updates, clinical trial insights, and more.

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"It's an exciting time" in dermatology, said Lee, who reflects on late-breaker data and other research presented at the 2024 AAD Annual Meeting.  

Jim Lee, MD, PhD, Reflects on New Research at AAD and Advances in Dermatology

Final Thoughts: The Importance of Comparative Studies in AD

Panelists offer concluding insights and emphasize the critical role of comparative studies in advancing atopic dermatitis treatment strategies.

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I'm sorry, but it seems there is no article text provided for me to summarize and extract key takeaways from. Could you please provide the text of the article

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POLL: What is the Most Common Type of Mole Found on Adults? 

Hyperhidrosis is not rare. According to the 

, approximately 385 million people worldwide live with hyperhidrosis.

In fact, they note that the amount of people living with chronic, excessive sweating is even higher than the amount of people living with other dermatologic conditions like psoriasis.

Just how common is hyperhidrosis in real-world comparisons?

The prevalence of hyperhidrosis is much higher in younger populations than in the general population, with 8.8% of individuals between the ages of 18 to 39 years old living with the condition. 

When comparing these statistics to everyday, common occurrences like hair color, the number of people with hyperhidrosis is greater than the 1% of individuals with natural red hair and 2% of individuals with natural blond hair. 

Despite how common hyperhidrosis is, it is estimated that 27% of those with the condition never receive a diagnosis.

 wants to hear from you. What percentage of the global population is estimated to have hyperhidrosis?

 to share your hyperhidrosis insights or research.

Albert. Fact check: Hyperhidrosis - International Hyperhidrosis Society: Official site. Home - International Hyperhidrosis Society. October 24, 1970. Accessed November 16, 2023. 

https://www.sweathelp.org/home/news-blog/542-fact-check-hyperhidrosis.html

Hyperhidrosis affects approximately 385 million people globally, surpassing the prevalence of other dermatologic conditions like psoriasis. It is notably more common in younger populations, with 8.8% of individuals aged 18 to 39 experiencing the condition. Comparatively, hyperhidrosis is more prevalent than natural red or blond hair, which affects 1% and 2% of the population, respectively. Despite its prevalence, 27% of those with hyperhidrosis remain undiagnosed. The article encourages engagement during Hyperhidrosis Awareness Month to share insights and research on the condition.

Click here to answer this week's poll for Hyperhidrosis Awareness Month.

POLL: What Percent of the Global Population is Estimated to Have Hyperhidrosis?

 conference in Nashville, Tennessee, Eli Lilly and Company shared final results from the phase 3b ADmirable trial of lebrikizumab (Ebglyss).

This is the first study to evaluate lebrikizumab’s effectiveness and safety in adult and adolescent patients with pigmented skin and atopic dermatitis (AD), as this population is typically underrepresented in clinical trials.

) included 90 patients 12 years and older (weight: ≥ 40 kg) with moderate to severe AD and pigmented skin, according to the Fitzpatrick skin type scale (IV, V, or VI). Participants self-identified as Black or African American, Asian, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander. The mean age of patients was 40.7 years. Approximately 43.3% of participants had a Fitzpatrick skin phototype of IV.

"Skin pigmentation matters in evaluating patients with atopic dermatitis, because from a medical perspective, the disease presents differently in darker skin tones vs lighter (eg, redness can be more subtle, pigmentation more prominent, and diagnosis and evaluation more challenging). Additionally, in the next 20 years, people who identify as American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian, or other Pacific Islander are projected to represent more than half of all Americans, which drives our urgency to invest in clinical research that helps address longstanding medical gaps in these populations. ADmirable is the first dedicated study to evaluate the efficacy and safety of Ebglyss in adult and adolescent patients with AD in these patients frequently underrepresented in clinical trials," said Anabela Cardoso, MD, senior vice president of immunology medical affairs at Eli Lilly and Company, in an interview with 

The patients received lebrikizumab 250 mg (500-mg loading dose at baseline and week 2) subcutaneously every 2 weeks for 16 weeks. Then, from weeks 16 to 24, those who responded to treatment received lebrikizumab 250 mg once every 4 weeks; those with inadequate response continued with the dosage every 2 weeks.

Respondents were defined as having an Investigator’s Global Assessment score of 0 or 1 with a 2-point or greater improvement (IGA 0/1) or 75% or greater improvement in Eczema Area and Severity Index (EASI 75). The primary end point of the study was achieving an EASI score of 75 at week 16. Secondary end points revolved around safety and efficacy using PDCA Derm, assessing cutaneous postinflammatory hyperpigmentation and hypopigmentation.

Approximately 68.9% of patients began the trial with moderate disease (IGA = 3) with a mean EASI of 26.4 and an average Pruritus Numeric Rating Scale (NRS) score of 7. At week 16, EASI 75, EASI 90, and IGA 0/1 were achieved by 69.2%, 44.9%, and 44.9% of patients, respectively. This includes more than 88% of patients with the darkest skin tones (Fitzpatrick V and VI). Approximately 73% of respondents were able to switch to a once-monthly maintenance dose after 16 weeks.

Nearly 60% of patients observed a 4-point or greater improvement in Pruritus NRS. These numbers increased at week 24 with EASI 75, EASI 90, and IGA 0/1 achieved by 78.4%, 47.3%, and 54.1% of patients, respectively. Moreover, 61.5% of participants had a 4-point or greater Pruritus NRS improvement.

"This new data demonstrating improvement in signs and symptoms (including itch) through 24 weeks of treatment helps confirm the efficacy of lebrikizumab in patients with skin of color – a population for which data is often lacking. Being able to communicate to my patients that the treatment I am recommending has established efficacy and safety in populations that reflect their background goes a long way in establishing trust and encouraging adherence to therapy," said Andrew Alexis, MD, professor of clinical dermatology and vice-chair for diversity and inclusion at Weill Cornell Medicine, in a statement to 

Additionally, 4-point or greater improvements in the Dermatology Life Quality Index were reached by 71.7% and 72.9% of patients at weeks 16 and 24, respectively. More than 64% of patients with hyperpigmented lesions and 25% with hypopigmented lesions showed improvement after 24 weeks. Most treatment-emergent adverse effects were mild or moderate, with only 1 reported case of conjunctivitis and injection site reaction. None of the adverse events were serious, and the drug did not need to be discontinued. This safety profile is consistent with previous long-term trials of lebrikizumab, regardless of dosage and frequency.

"Being able to communicate to my AD patients with skin of color that treatment with lebrikizumab has a high success rate in improving not only the signs and symptoms of AD, but also the sequela of postinflammatory hyperpigmentation, is extremely impactful and aligns with their treatment goals," said Alexis.

Overall, patients with skin of color and moderate to severe AD severity responded well to lebrikizumab after 24 weeks, with improvements in symptoms such as itch and hyperpigmentation. Response was noted as early as week 16 and continued to improve throughout the trial with a favorable safety profile.

"These new, 24-week data from ADmirable—the first dedicated study for evaluating the efficacy and safety of Ebglyss in adult and adolescent patients with pigmented skin and moderate-to-severe atopic dermatitis—reinforce the efficacy and safety of Ebglyss as a first-line biologic, following prescription topicals, with once-monthly maintenance dosing after the 4-month initial dosing for adults and adolescents, regardless of skin tone. These add to the robust and extensive data supporting Ebglyss's value for a broad range of patients with moderate to severe atopic dermatitis," Cardoso concluded.

1. Alexis A, Moiin A, Waibel J, et al. Efficacy and safety of lebrikizumab in adult and adolescent patients with skin of color and moderate-to-severe atopic dermatitis: final 24-week results from the phase 3b, open-label ADmirable study. Presented at: 2025 Revolutionizing Atopic Dermatitis (RAD) Conference; June 6-7, 2025; Nashville, TN.

2. Lilly's Ebglyss (lebrikizumab-lbkz) single monthly maintenance injection achieved completely clear skin at 3 years in half of patients with moderate-to-severe atopic dermatitis. News release. Eli Lilly. March 7, 2025. Accessed June 7, 2025. 

https://investor.lilly.com/news-releases/news-release-details/lillys-ebglyssr-lebrikizumab-lbkz-single-monthly-maintenance

Lebrikizumab demonstrated efficacy and safety in treating moderate-to-severe atopic dermatitis (AD) in patients with pigmented skin, a group often underrepresented in clinical trials. The phase 3b ADmirable trial included 90 participants aged 12 and older, with significant improvements observed in Eczema Area and Severity Index (EASI) and Pruritus Numeric Rating Scale (NRS) scores by week 16, which further improved by week 24. The study reported a favorable safety profile, with most adverse effects being mild or moderate, and no serious events necessitating discontinuation of the drug.

At RAD 2025, Eli Lilly revealed promising results for lebrikizumab in treating atopic dermatitis in patients with skin of color.

Late-Breaking Data: Lebrikizumab Demonstrates Efficacy in Patients With Skin of Color With AD

As we begin 2025 with a new president and a Republican majority in both houses of Congress, it is a good time to consider aspects of the current tax law that are set to expire at the end of 2025, as well as various tax proposals President Donald Trump made throughout his campaign. Understanding these potential changes will help you implement tax planning for 2025 and beyond.

The Tax Cuts and Jobs Act (TCJA), enacted in December 2017, introduced substantial amendments to the US tax code, aiming to streamline tax processes, provide economic stimulation, and foster investment. These changes affected various aspects of individual and corporate taxation. While some provisions are temporary, others offer long-term shifts in taxation policy. Here, we will examine some of the temporary provisions set to expire December 31, 2025, along with proposals President Trump has made regarding those provisions.

The TCJA reduced tax rates for most individual taxpayers, with the top rate falling to 37% from the previous 39.6%. This reduction benefited high-income earners but was designed to cover a broad swath of income brackets, providing financial relief across socioeconomic groups.

A significant change under the TCJA was the doubling of the standard deduction to what is for 2025 $15,000 for individuals and $30,000 for married couples. These adjustments reduced the number of taxpayers itemizing deductions, simplifying the tax filing process for many.

The TCJA doubled the child tax credit to $2000 per child and expanded its eligibility criteria, allowing more families to qualify. Up to $1400 of the credit became refundable, enabling low-income families with little tax liability to benefit.

The TCJA capped the state and local tax (SALT) deduction at $10,000, significantly impacting taxpayers in high-tax states. Critics argued that this disproportionately affected those in states with substantial state and local taxes.

The TCJA essentially doubled the estate tax exemption, which has since been indexed for inflation to its current 2025 level of $13.99 million per individual. Estates with taxable assets above this amount will be taxed at 40%.

Barring passage of any new federal tax law, as of January 1, 2026:

Individual tax brackets will revert to previous levels, with the top tax bracket at 39.6%.

The standard deduction will be halved, making it more beneficial for many taxpayers to itemize deductions again.

The cap for mortgage acquisition debt on which interest is deductible will go back to $1 million from the current $750,000.

State and local income taxes and real estate and property taxes will again be fully deductible.

The federal estate tax exemption will be cut in half.

During his campaign, however, President Trump presented proposals that could modify these provisions or eliminate the year-end expiration date. These include making permanent the lower tax brackets and increased standard deduction, as well as increasing the child tax credit to $5000 per child without income limits, an adjustment intended to provide more support for families, particularly in light of rising childcare costs. He also mentioned allowing the cap on state and local income tax (SALT) deductions to lapse, restoring higher deduction possibilities, and proposed additional deductions for interest on loans for US-built cars and for home generators in natural disaster-prone areas. He has also suggested making the higher estate tax exemption permanent or repealing the estate tax altogether.

The TCJA introduced a 20% deduction for qualified business income from pass-through entities (eg, LLCs, partnerships, and S corporations). This provision is also temporary, expiring in 2025. President Trump proposed making this deduction permanent, citing its importance for small businesses. However, medical practices are considered a specified service trade or business (SSTB) and are not eligible for this deduction unless an individual taxpayer’s income is below certain threshold amounts ($494,600 for married taxpayers filing jointly in 2025).

Tax rates for C corporations were permanently reduced to 21% under the TCJA. President Trump, however, has proposed a further rate cut for corporations to 20% or even 15%.

The general expectation is that President Trump will try to pass a new tax law early in his term since Republicans have a majority in both houses. If individual tax rates continue at a top rate of 37%, with expanded brackets of lower tax rates, continuing to fund Roth IRA accounts will make sense for many taxpayers. Recent gains in the stock market have increased the balances in qualified retirement plans. Traditional plans such as 401(k)s, 403(b)s, and IRAs will have required minimum distributions (RMDs) when taxpayers reach age 73 or 75, depending on their year of birth. Roth accounts do not have such requirements. For those who have more savings in retirement plans than they will need, converting some of the funds to a Roth, or adding current funding to Roth accounts, could make sense.

If the SALT cap is allowed to expire while standard deduction increases are extended, many taxpayers will again find it more beneficial to itemize deductions rather than take the increased standard deduction. Allowing the mortgage interest deduction on up to $1 million of debt would further enhance itemized deductions for many taxpayers. Itemizing deductions will also make charitable contributions more beneficial; thus, donating appreciated assets to charity can be a key component of efficient giving.

For taxpayers who are owners of pass-through entities, an extension of the Section 199A qualified business income (QBI) deduction will extend the tax cuts on business income. If that business is an SSTB such as a medical practice, utilizing tools such as a cash balance plan to increase deductions may help bring taxable income below the threshold amounts, thereby making the QBI deduction allowable.

Efficient tax planning in 2025 will require paying attention to proposed tax law changes and working with your advisers when any new legislation is passed to make sure you fully understand how to create a tax-efficient wealth plan.

 is a certified public accountant and author of more than a dozen books for physicians. She is a partner in the wealth management firm OJM Group (

) and can be reached at 877-656-4362 or 

OJM Group, LLC (“OJM”) is an SEC-registered investment adviser with its principal place of business in the State of Ohio. SEC registration does not constitute an endorsement of OJM by the SEC nor does it indicate that OJM has attained a particular level of skill or ability. OJM and its representatives are in compliance with the current notice filing and registration requirements imposed upon registered investment advisers by those states in which OJM maintains clients. OJM may only transact business in those states in which it is registered or qualifies for an exemption or exclusion from registration requirements. For information pertaining to the registration status of OJM, please contact OJM or refer to the Investment Adviser Public Disclosure web site 

For additional information about OJM, including fees and services, send for our disclosure brochure as set forth on Form ADV using the contact information herein. Please read the disclosure statement carefully before you invest or send money.

This article contains general information that is not suitable for everyone. The information contained herein should not be construed as personalized legal or tax advice, or as a recommendation of any particular security or strategy.

There is no guarantee that the views and opinions expressed in this article will be appropriate for your particular circumstances. Tax law changes frequently; accordingly, information presented herein is subject to change without notice. You should seek professional tax and legal advice before implementing any strategy discussed herein.

As 2025 begins with a new administration and Republican congressional majority, attention turns to the expiring provisions of the Tax Cuts and Jobs Act (TCJA) and President Trump's tax proposals. Key TCJA provisions set to expire include lowered tax brackets, increased standard deductions, and enhanced child tax credits. Trump's proposals aim to make these changes permanent, increase the child tax credit, and adjust SALT deductions. Tax planning strategies should consider potential legislative changes, focusing on Roth IRA conversions, itemized deductions, and qualified business income deductions for pass-through entities.

Key 2025 tax law changes for dermatologists include expiring TCJA provisions, potential rate adjustments, and new deduction policies under Trump.

Potential 2025 Tax Law Changes: What Dermatologists Should Know

Thus far, 2025 has been a challenging year for investors. Pullbacks in the US and other stock markets due to tariff policy and the fear of trade wars have cost investors dearly over the first 2 quarters. Some dermatologists may see this increased volatility and be fearful of what comes next. They might even consider selling their investments and “going to cash.”

An emotional reaction to a stock market decline is natural, but as we hope to show you in this short article, reason should rule the day. Fortunately, we have decades and even centuries of data to call upon when looking at market downturns, which can be helpful to calm even the most worried physicians. In fact, we often come back to the short adage that summarizes what history tells us when it comes to investing: “Time in the market beats timing the market.”

Let us begin with the opposite concept: attempting to “time” the market by buying before run-ups, selling somewhere near the top, and then buying back in once prices have come down. In essence, market timing means selling assets when one thinks the market will continue to decline and then buying back in when it feels safe that the market has bottomed out. This may sound enticing in theory.

In practice, however, the evidence is overwhelming that most investors diminish their long-term returns by trying to employ a market timing strategy. They are more likely to chase the market up and down and be whipsawed by buying high and selling low. Market timing, although tempting, involves getting 2 nearly impossible decisions right: when to sell and when to buy back in.

 shows that the 15 best days for the S&P 500 (through December 31, 2023) all occurred within bear markets, not in bull markets as you might expect.

In other words, the best days to be in the market have been when it is hardest to remain invested or most tempting to exit the market and wait for better days. Looking at these dates, you will find the “who’s who” of dark times for the stock market: the 2008 financial crisis, the dot-com crash, and the Black Monday crash of 1987. A handful of these best days happened in the first quarter of 2020, during the onset of the COVID-19 pandemic.

This trend continued in a recent market pullback in spring 2025. In the midst of a significant downtrend in April, the S&P 500 index had one of its highest 1-day returns ever on Wednesday, April 9, 2025—a 9.5% rise.

Missing just the 10 best days in a 20-year period can have a significant long-term effect on a portfolio. For example, an investor who invested $10,000 in the S&P 500 in 2003 would have finished with a portfolio value of more than $64,000 (as of December 31, 2022) if they had remained fully invested. However, the portfolio value for an investor who missed the 10 best days is much lower: less than $30,000. Of course, the results worsen as more of the market’s best days are missed. In fact, returns on the portfolio were almost entirely eliminated if the investor missed just 30 of the market’s best days in the 20-year period (

One does not necessarily need a 20-year period to experience the lost opportunity from missing just a few trading days. In fact, the concepts illustrated in 

 were well defined in the single year between January 1 and December 31, 2020. For example, a portfolio valued at $1 million on January 1 would have been reduced to $695,730 at the market’s lowest point on March 23. If no withdrawals were made throughout the year, the portfolio’s balance on December 31 would have reached $1,184,000. For this hypothetical portfolio, exiting the market at its low point vs remaining invested all year would have resulted in the difference between a 30.4% loss and an 18.4% overall gain.

 Of course, it is unlikely an investor will miss only the best days if they attempt to time the market. They might also be able to miss some of the historically bad days. However, the cautionary tale of attempting to time the market is the same: There can be an enormous cost to pay if the market swings to the upside while you are on the sidelines. It would take a crystal ball to enter and exit the market perfectly, particularly because it needs to be done in short order given the market’s best and worst days tend to cluster close to one another. Investors should also be aware of the tax implications associated with selling assets in an attempt to time the market.

When an investor experiences losses beyond their acceptable threshold, the temptation to abandon the current strategy intensifies. Every investor is likely to lose money in their lifetime. A key to success is avoiding the urge to lock in losses when times appear the bleakest. Cashing out your investments can be costly because the recoveries are often sharp and swift. Once the news is positive, a sizable portion of the gain is likely in the rear-view mirror. Missing the bounce may teach an expensive lesson.

 are the reason astute investors do not engage in all-in and all-out strategies. Timing the market once is difficult, but timing it twice is nearly impossible.

By encouraging you to spend “time in the market,” we mean for you to adhere to your long-term financial and investment plan. Although this may mean adjusting allocations (and thus selling and buying portions of a portfolio), the key is that the actions are taken with a long-term view and time horizon. Rather than trying to predict what will happen in the market tomorrow or next week or even next year, you invest for long-term financial goals, such as children’s education or retirement, which can be decades away. In doing so, you can benefit from the long-term upward trends of markets rather than the up-and-down bumps and dips along the way.

, is an attorney and author of more than a dozen books for physicians. He is a partner in the wealth management firm OJM Group.

Morningstar data and analytics. Morningstar. Accessed April 29, 2025. 

https://www.morningstar.com/business/brands/data-analytics

YCharts database. YCharts. Accessed April 29, 2025. 

Investors have faced challenges in 2025 due to market volatility driven by tariff policies and trade war fears. Emotional reactions to market declines are common, but historical data suggests that maintaining investments is more beneficial than attempting to time the market. Market timing often results in missed opportunities, as the best market days typically occur during downturns. Missing just a few of these days can significantly impact long-term returns. Instead, a long-term investment strategy focused on enduring market fluctuations is recommended for achieving financial goals.

Market pullbacks tempt investors to time the market, but history shows staying invested beats guessing the highs and lows—time > timing.

Jim Lee, MD, PhD

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