Shanna Miranti, MPAS, PA-C; Tina Bhutani, MD; and Walter Liszewksi, MD, discuss the burden of moderate to severe pediatric atopic dermatitis (AD) on both patients and their caregivers. The panelists review the 3 available non-steroidal topicals, their itch data, skin clearance rates, and how topicals and systemics can be combined to best support pediatric patients.